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Selected Publications in Chronic Liver Disease

Dr. Angela Crawley PubMed
Crawley lab members in ​bold
Dec, 2021
​BATL: Bayesian annotations for targeted lipidomics

Sept, 2021
​TLR-4 agonist induces IFN-g production selectively in pro-inflammatory human M1 macrophages through the PI3K-mTOR, p38 and JNK-MAPK activated p70S6K pathway

April 2021
​Symptoms, pulmonary function and functional capacity four months after COVID-19

Jan, 2021
​​Selective killing of human M1 macrophages by Smac mimetics alone and M2 macrophages by Smac mimetics and caspase inhibition




​May, 2020
​
IL-7 induces sCD127 release and mCD127 downregulation in human CD8+ T cells by distinct yet overlapping mechanisms, both of which are impaired in HIV infection

​Aug, 2020
​
Expression of inhibitory receptors on T and NK cells defines immunological phenotypes of HCV patients with advanced liver fibrosis

Jan 2020,
​In vitro hepatitis C virus infection and hepatic choline metabolism

Aug, 2019
Dysfunction of bulk circulating CD8+ T-cells in chronic HCV infection is associated with liver disease severity and is unresolved after HCV cure

Jul, 2019​

​Evaluation of safety and effectiveness of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (E/C/F/TAF) Switch followed by Ledipasvir-Sofosbuvir HCV Therapy in HIV-HCV Co-Infection

​Apr, 2019
​Macrophage subsets are dysfunctional in chronic HCV infection and contribute to CD8+ T-cell impairment

​Mar, 2019
​Influence of Ribavirin and the Cirrhotic State on Metabolic Measures in Hepatitis C Direct Acting Antiviral Treatment Recipients

​Jul, 2018
​6th Canadian Symposium on HCV: Delivering a Cure for Hepatitis C Infection: What are the Remaining Gaps?

​Jan, 2018
​Hepatitis C virus core protein reduces CD8+ T-cell proliferation, perforin production and degranulation but increases STAT5 activation


Dec, 2017
​Increase in soluble IL-7 receptor levels in plasma is associated with improved therapeutic outcome to IL-7 therapy in SIV-infected ART-treated Rhesus macaques

​
Apr, 2016
​Influence of female sex on hepatitis C virus infection progression and treatment outcomes. European Journal of Gastroenterology and Hepatology

​Jun, 2016
​
Generalized Liver- and Blood-Derived CD8+ T-Cell Impairment in Response to Cytokines in Chronic Hepatitis C Virus Infection

​Mar, 2012
​he influence of HIV on CD127 expression and its potential implications for IL-7 therapy

​Mar, 2012

In vitro HIV Type 1 infection indirectly alters CD127 expression on CD8+ T-cells

Aug, 2011
Expression of g-chain cytokine receptors on CD8+ T-cells in HIV infection with a focus on IL-7Ra (CD127)

Apr, 2011
IL-7-dependent STAT-5 activation and CD8+ T-cell proliferation are impaired in HIV infection

Dec, 2010
The role of IL-7 in memory CD8+CD127+ T-cell function and its impairment in HIV disease

​May, 2010
Interleukin-4 downregulates CD127 expression on human thymocytes and mature CD8+ T-cells​

​
May, 2010
Soluble IL-7Ra (sCD127) inhibits IL-7 activity and is increased in HIV infection

Aug, 2009
​Development of a Quantitative Bead Capture Assay for Soluble IL-7 Receptor a in Human Plasma

Jan, 2009
 IL-2 receptor g chain cytokines differentially regulate human CD8+CD127+ and CD8+CD127- T-cell division and susceptibility to apoptosis

Dec, 2007
IL-7 decreases IL-7 receptor-α (CD127) expression and induces shedding of CD127 by human CD8+ T cells

​
​2021​
  1. Chitpin JG., Surendra A., Nguyen TT., Taylor GP., Xu H., Alecu I., Ortega R., Tomlinson JJ., Crawley AM., McGuinty M., Schlossmacher MG., Saunders-Pullman R., Cuperlovic-Culf M., Bennett SAL., Perkins TJ. BATL: Bayesian annotations for targeted lipidomics. Bioinformatics, impact factor 6.9 (Accepted, December 2021).
  2. Gajanayaka N., Iqbal S., Mookerjee A., Ahmed F., Ali H., Lawton, D., Angel JB., Crawley AM., Kumar A. TLR-4 agonist induces IFN-g production selectively in pro-inflammatory human M1 macrophages through the PI3K-mTOR, p38 and JNK-MAPK activated p70S6K pathway. J. Immunol., Sept. 2021 PMID: 34551966.
  3. Abdallah SJ., Voduc N., Corrales-Medina V., McGuinty M., Pratt A., Chopra A., Law A., Garuba HA., Thavorn K., Reid RER., Lavoie KL., Crawley AM., Chirinos JA., Cowan J. Symptoms, pulmonary function and functional capacity four months after COVID-19. Annals of ATS (accepted April 2021) PMID: 33872135.
  4. Ali H., Caballero R., Iqbal S., Gajnayaka N., Ahmed D., Dong S., Vranjkovic A., Crawley AM., Angel JB., Cassol E., Kumar A. Selective killing of human M1 macrophages by Smac mimetics alone and M2 macrophages by Smac mimetics and caspase inhibition. J. Leuk. Biol. 2021, 110:693–710.
2020
  1. ​Côté, SC., Burke Schinkel, SC., Berthoud TK., Barros PO., Sanchez-Vidales M., Davidson AM., Crawley AM., Angel JB. IL-7 induces sCD127 release and mCD127 downregulation in human CD8+ T cells by distinct yet overlapping mechanisms, both of which are impaired in HIV infection. Eur. J. Immunol., 2020. 50:1537-49.
  2. Okwor CIA., Oh JS., Crawley AM., Cooper CL., Lee SH. Expression of inhibitory receptors on T and NK cells defines immunological phenotypes of HCV patients with advanced liver fibrosis. (iScience, 2020. 23(9): 101513).
  3. Odai KG., O’Dwyer C., Steenbergen R., Shaw T., Renner T., Ghorbani P., Langlois M-A., Crawley AM., Russell RS., Pezacki J., Tyrrell LD., Fullerton MD. In vitro hepatitis C virus infection and hepatic choline metabolism. Viruses, 12(1). pii: E108, 2020.
2019
  1. Vranjkovic A., Deonarine F., Angel JB., Cooper CL., Crawley AM. Dysfunction of bulk circulating CD8+ T-cells in chronic HCV infection is associated with liver disease severity and is unresolved after HCV cure. Frontiers Immunol., 10:1926, 2019.
  2. Doyle MA., Lee T., Singer J., Crawley AM., Klein M., Cooper CL. Evaluation of safety and effectiveness of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (E/C/F/TAF) Switch followed by Ledipasvir-Sofosbuvir HCV Therapy in HIV-HCV Co-Infection. Open Forum Infectious Diseases 6(7). pii: ofz318 2019.
  3. Ahmed F., Ibrahim A., Cooper CL., Kumar A., Crawley AM. Macrophage subsets are dysfunctional in chronic HCV infection and contribute to CD8+ T-cell impairment. Cells 2019, 8:374 - Special Issue: Hepatitis C Virus and Host Interactions, by invitation.
  4. Doyle M-A., Mulvihill E., Galanakis C., Crawley AM., Cooper CL. Influence of Ribavirin and the Cirrhotic State on Metabolic Measures in Hepatitis C Direct Acting Antiviral Treatment Recipients. Cells 2019, 8:252 -Special Issue: Hepatitis C Virus and Host Interactions, by invitation.
2018
  1. Khan S., Bernier, A., Dapp D., Fortier E., Krajden M., King A., Grebely J., Sagan SM., Cooper CL., Crawley AM. 6th Canadian Symposium on HCV: Delivering a Cure for Hepatitis C Infection: What are the Remaining Gaps? Can. Liver J. 2018, Vol 1(2):94-105.
  2. Khan S., Karges W., Cooper C., Crawley AM. Hepatitis C virus core protein reduces CD8+ T-cell proliferation, perforin production and degranulation but increases STAT5 activation. Immunol. 2018 154(1):156-65.
2017
  1. Steele (Leone) A.K., Carrasco-Medina L., Sodora D.L., Crawley AM. Increase in soluble IL-7 receptor levels in plasma is associated with improved therapeutic outcome to IL-7 therapy in SIV-infected ART-treated Rhesus macaques. PlosOne 2017, 12(12): e0188427.
2016
  1. Corsi DJ., Karges W., Thavorn K., Crawley AM., Cooper CL. Influence of female sex on hepatitis C virus infection progression and treatment outcomes. European Journal of Gastroenterology and Hepatology. 2016 28(4): 405-411.
  2. Burke-Schinkel SC,  Carrasco-Medina L, Cooper CL, Crawley AM. 2016. Generalized Liver- and Blood-Derived CD8+ T-Cell Impairment in Response to Cytokines in Chronic Hepatitis C Virus Infection. PLOS ONE.. 
2012
  1.  Crawley AM., and Angel JB. 2012. The influence of HIV on CD127 expression and its potential implications for IL-7 therapy. (Invited review article for Semin. Immunol., 24:231-240.
  2. Vranjkovic A., Crawley AM., Patey A., Angel JB. 2012. In vitro HIV Type 1 infection indirectly alters CD127 expression on CD8+ T-cells. AIDS Research and Human Retrovirology. 28:295-298.
2011
  1. Crawley AM., and Angel JB. 2011. Expression of g-chain cytokine receptors on CD8+ T-cells in HIV infection with a focus on IL-7Ra (CD127). Immunol. Cell. Biol. 90:379-387.
  2. *Vranjkovic A., Crawley AM., Patey A., Angel JB. 2011. IL-7-dependent STAT-5 activation and CD8+ T-cell proliferation are impaired in HIV infection. J. Leuk. Biol., 89:499-506.  Note: An editorial introduces this article in its issue: Paiardini M. et al., 2011. J. Leuk Biol. 89:491-3.
2010
  1. O’Connor A., Crawley AM., Angel JB. 2010. The role of IL-7 in memory CD8+CD127+ T-cell function and its impairment in HIV disease. Immunol., 131(4):525-536.
  2. Crawley AM., Vranjkovic A., Young C., Angel JB. 2010. Interleukin-4 downregulates CD127 expression on human thymocytes and mature CD8+ T-cells. Eur. J. Immunol., 40:1396-1407.
  3. Crawley, AM., Faucher S., Angel JB. 2010. Soluble IL-7Ra (sCD127) inhibits IL-7 activity and is increased in HIV infection. J. Immunol., 184:4679-4787.
2009
  1. Faucher S., Crawley AM., Decker W., Sherring A., Bogdanovic D., Ding T., Bergeron M., Angel JB., Sandstrom P. 2009. Development of a Quantitative Bead Capture Assay for Soluble IL-7 Receptor a in Human Plasma. PLoSONE, 4(8): e6690.
  2. Crawley AM., Katz T., Parato KP., Angel JB. 2009. IL-2 receptor g chain cytokines differentially regulate human CD8+CD127+ and CD8+CD127- T-cell division and susceptibility to apoptosis. Int. Immunol., 21: 29-42
2007
  1. Vranjkovic A.*, Crawley AM.* Gee K., Kumar A., Angel JB. 2007. IL-7 decreases IL-7 receptor-α (CD127) expression and induces shedding of CD127 by human CD8+ T cells. Int. Immunol., 19: 1329-1339. (*contributed equally).
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